Abdul Rehman, Sultan Ahmed Shah, Khan R A.
Comparison of Myocardial Perfusion imaging studies with Technetium 99` Tetrofosmin and Coronary Angiography findings in non-diabetic and diabetic patients of Ischemic Heart Disease.
Pak J Cardiol Jan ;14(1):15-21.

The main objective of this study was to compare the results of myocardial perfusion imaging studies with Tc99` tetrofosmin and coronary angiography finding in non-diabetic and diabetic patients of ischemic heart disease. This study compared the results of Single Photon Emission Computed Tomographic (SPECT) imaging with technetium-99m tetrofosmin with those of coronary angiography findings in non-diabetic and diabetic patients of ischemic heart disease. Total 35 patients were included in this study and divided in to two groups, the diabetic group and non-diabetic group. Out of 35 patients 18 were were non-diabetics and 17 were diabetics. All the patients underwent stress/rest imaging with technetium tetrofosmin and coronary angiopgraphy. SPECT images were divided in to five segments per patients and >= 70% occlusion of coronary artery were considered to be significant. In comparison with nondiabetic from diabetics, the diabetics have significant number of reversible ischemia in anterior wall (p=0.023) although the angiography findings showed no significant difference in the severity of disease in left anterior descending coronary artery that is the main coronary artery to supply the anterior wall. This shows that due to diffuse disease in diabetics the severity of disease could not be assessed correctly by coronary angiography because due to diffuse nature of disease there is a lack of normal lumen for comparison. Therefore in diabetics myocardial perfusion imaging is more informative as compared to non-diabetics.

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