Hafiz Muhammad Yaqoob, Abdul Qadir Khan, Muhammad Jameel, Naveed Ullah Khan, Syed Asim Sherazi, Zeeshan Khan.
Comparison of perioperative use of tranexamic acid with placebo in patients with hip fractures in terms of frequency of deep venous thrombosis.
Pak Armed Forces Med J Jan ;70(1):68-72.
Objective: To compare perioperative use of tranexamic acid with placebo in patients with hip fractures in terms of frequency of deep venous thrombosis. Study Design: Quasi experimental study. Place and Duration of Study: CMH Orthopedics department Rawalpindi, from Apr 2017 to Oct 2017. Methodology: A total of 306 patients presenting with hip fracture, 50 to 90 years of age were included. Patients with Hip fractures presenting with sepsis, hypercoagulable state, pregnancy and breast feeding and contra-indication to tranexamic acid were excluded. The sample size was divided into two equal groups by lottery method, Tranexamic Acid (TXA) and Placebo. The patient was followed till 15th post op day for the purpose of study and at 15th post op day a Doppler ultrasound was performed on both lower limbs and presence or absence of deep venous thrombosis was recorded. Results: The mean age of patients in group A (tranexamic acid group) was 70.80 ± 11.13 years and in group B (placebo group) was 71.50 ± 11.30 years. Out of these 306 patients, 215 (70.26%) were male and 91 (29.74%) were females. Deep venous thrombosis was seen in 31 patients in group A (tranexamic acid group) and 14 patients in group B (placebo group) with p-value of 0.006. Conclusion: Frequency of deep venous thrombosis was observed more in patients receiving perioperative intravenous tranexamic acid as compared to control.
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