Muhammad Ammar Rashid, Tahir Naveed, Naveed Ahmed Shahid, Muhammad Atif Imran, Zeeshan Malik, Muhammad Irfan Tahir Khan.
Association Acute Hyperglycemia with Mortality During Hospital Stay in patients Presenting with Acute Myocardial Infarction.
J Cardiovascular Dis Jan ;15(4):104-8.

There is significant effect on morbidity and mortality of acute myocardial infarction with metabolic abnormalities. Out of which most common and easily detectable abnormality is raised plasma glucose level which may be associated with poor outcome of patients with acute coronary syndrome frequently it has been seen that patients with myocardial infarction has abnormal glucose tolerance. This study was planned to determine the association acute hyperglycemia with mortality during hospital stay in patients with acute myocardial infarction. MATERIAL AND METHODS: This was an observational, Cohort study conducted at Department of Cardiology, PIC, Lahore. The duration of study was six months after the approval of ethical committee. 310 patients fulfilling the selection criteria were included in the study. The patients were divided in two groups i.e. group I with acute hyperglycaemia and group II with normal glycaemic level. The patients were evaluated after 5 days. If patient died during hospital stay, inhospital mortality was labeled. The association between acute hyperglycaemia and mortality during hospital stay was calculated as Relative risk (RR). RR>1 was considered as significant. RESULTS: The mean age of patients with hyperglycaemia was 57.71+-11.64years. The mean age of patients with normal glycaemia level was 58.25+-11.84years. There were 101 (65.2%) males and 54 (34.8%) females in hyperglycemia group. There were 93 (60.0%) males and 62 (40.0%) females in normal glycemic group. In hyperglycemia group, 24 (15.5%) patients had mortality during hospital stay while in normal glycemic group, 8 (5.2%) patients had in-hospital mortality. There were 3.0 times more chances of mortality during hospital stay in hyperglycemic patients i.e. RR= 3.0 (95% CI; 1.391, 6.470, p<0.05). CONCLUSION:In-hospital mortality is three times more in patients with hyperglycemia admitted with acute myocardial infarction.

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