Raana Mahmood, Itrat Jawed, Nosheen, Raheela Najam, Nargis Anjum, Bushra Z Sayeed, Faiza Zafar.
Study of Analgesic Activity of Methanolic Extracts of Cuminum Cyminum (L.) and Centratherum Anthelminticum (L.) in Mice.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;24(2):90-5.

Objective: This study was conducted to investigate and compare the analgesic activity of methanolic extracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L)in mice. Methods: This study was conducted in the department of Pharmacology University of Karachi; 30 healthy mice were selected from animal house of Pharmacology department of University of Karachi for the study. All animals were divided into three groups, each group of 10 mice. Mice of Group 1 were given DMSO (Dimethyl sulphoxide) an organic solvent, mice of group 2 were given Methanolic extract of Cuminum Cyminum (L) and mice of group 3 were given Methanolic extract of Centratherum anthelminticum (L). The analgesic activity was investigated by tail flick test, heat is used to stimulate pain and observe analgesic activity, after a week of oral dosing of Methanolic extracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L) in mice. Methanolic extracts of Cuminum Cyminum (L) and Centratherum anthelminticum (L) were insoluble in water so Dimethyl sulphoxide (DMSO) i.e. an organic solvent was used in this study (it is used for solutes that are insoluble in water). The methanolic extracts of Cuminum cyminum(L), Centratherum anthelminticum (L) and DMSO (dimethyl sulphoxide) were administered orally to three groups of mice for a week and on 7th day of dosing analgesic activity was tested through tail flick test, response is checked after 30, 60, 90, 120, 150, 180 and 240 minutes of 7th day of dosing. Results: The group of mice, which were given Methanolic extract of Cuminum cyminum(L)showed highly significant analgesic activity after 60, 90, 120, 150, 180 and 240 minutes of dosing. The group of mice which was given Methanolic extract of Centratherum anthelminticum (L) showed significant analgesic activity after 60, 90, 120, 150, 180 andhighly significant analgesic activity after 240 min. of dosing on 7th day. Conclusion: The results indicate that both extracts of Cuminum Cyminum (L) and Centratherum anthelminticum (L)showed analgesic activity. On comparison Cuminum Cyminum (L) have more superior analgesic potential than Centratherum anthelminticum (L).

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