Atteaya Zaman, Amena Rahim, Aqsa Malik.
Correlation of Cystatin C with Glomerular Filtration Rate and Urine Albumin - an early prediction of kidney status in type 2 Diabetes Mellitus.
Isra Med J Jan ;11(5):359-62.

Objective: To correlate Cystatin C with GFR and urinary albumin in order to find it out as a marker of early detection of kidney disease (diabetic nephropathy). Study Design: A cross sectional analytic study Place and Duration: The Department of Biochemistry, Islamic International Medical College from 15th March, 2016 to 14th March, 2017. Methodology: The diabetic patients having urinary albumin creatinine level between 30 mg/g to 300 mg/g were selected. The estimation of urinary albumin levels and cystatin C levels were carried out on IMAGIN Specific Protein Analyzer. GFR was calculated using standardized clinical and pathological parameters of creatinine levels, patients age, gender and body size and a cutoff value of GRF of < 60 ml was set for probable nephropathy. Results: Mean age of patients was 56.1 ± 5.4 years with male predominance (58.5%). Non-parametric spearman`s correlation coefficient found out that GFR was negatively correlated with Cystatin C (-.305). The correlation coefficient for and Cystatin C and urinary albumin was (0.517) showing a perfect positive linear relation. Conclusion: Cystatin C was found significantly correlated with GFR and urinary albumin, thus, validating previous findings regarding Cystatin C`s role as an early marker of kidney diseases.

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