Asma Danish, Zainab Sharif, Saima Munzir, Tahir Sultan Shamsi.
Hodgkin lymphoma in a child presenting as hlh (haemophagocytic lymphohistiocytosis)-ebv is central to both entities: a case report and review of literature.
Natl J Health Sci Jan ;4(3):119-22.

HLH is a rare life threatening systemic disease resulting from unregulated immune activation presenting with diverse clinical manifestations and etiologies. While Primary or familial HLH is a relatively common occurrence in infants and young children, secondary HLH due to infections, malignancy, rheumatologic and autoimmune disorders is infrequent and carries a grave prognosis owing to delayed or misdiagnosis. Albeitits rarity in children, EBV infection remains the leading cause of both Hodgkin`s lymphoma and HLH worldwide. Additionally, data for simultaneous presence of these three entities at the time of diagnosis is limited. Our report focuses on one such case where a patient`s clinical signs and symptoms were non-specific and masked by previous history of idiopathic HLH. After being in remission for 2-3 months patient again relapsed but this time around the etiology was Hodgkin`s lymphoma with an underlying EBV infection.

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