Muhammad Junaid, Naik Muhammad, Muhammad Umair, Asad Arif Ullah, Israr Uddin.
The effectiveness of topical intranasal steroid versus systemic anti-allergic drugs in allergic rhinitis: a randomized controlled trial.
J Med Sci Jan ;28(1):50-4.

Objectives: To compare efficacy of mometasone furoate topical intranasal therapy alone and combination of oral anti-hista-mine and anti-leukotriene therapy in seasonal allergic rhinitis.Methods: A randomized control trial at Department of Otorhinolaryngology, Head and Neck surgery, Pakistan Institute of Medical Sciences, Islamabad, and Khyber Teaching Hospital, Peshawar-Pakistan, was done in 1 year, from 25th Oct 2016 to 24th Oct 2017. A total of 146 patients were selected and divided into group A & group B (each group have 73 patients). The treatment given was topical Steroid (Mometasone) to Group A and oral antihistamine (loratadine 10mg), antileukotriene (Montelukast 10mg) to Group B. All patients who were included in our study were examined on three consecutive occasions, i.e. at zero presentation day, at 2 weeks and 4 weeks. Patient nasal symptom score was recorded and improvement noticed.Results: All 146 patients were selected and were divided into two groups with each group consists of 73 (50%) patients. Male to female ratio was 1:1.8 and mean age was 27.93+7.8. Out of all patients 124 (84.9%) were responders and 22 (15%) were non-responders. 69 (94.5%) patients of group A were responders while 4 (5.5%) were non-responders. On the other hand, in group B, 55 (75.3%) were responders and 18(24.7%) were non-respondersConclusion: Intranasal Mometasone furoate spray as a first line therapy was more effective than combined oral anti-hista-mines and leukotriene receptor antagonistsin allergic rhinitis.

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