Vaqar Ilahi Paracha, Tehseen Ahmed, Kaleem Ahmad, Anas Ahmad, Mehboob Sultan.
Experience of dual topical antibiotics for prevention of sternal wound infection in coronary artery bypass grafting surgery.
Isra Med J Jan ;11(6):425-9.

Objective: To determine the role of dual topical antibiotics for prevention of sternal wound infection in patients undergoing coronary artery bypass grafting surgery. Study Design: Comparative cross-sectional study. Place and Duration: Cardiac Surgical department Army Cardiac Centre Lahore from 1st Aug, 2017 to 31st July, 2018. Methodology: Data was collected on 134 consecutive patients of coronary artery bypass grafting surgery (both Off-Pump & On-Pump) and were divided into two equal groups. Group A includes patients with use of dual topical antibiotics (Topical Cefoperazonesulbactam and topical Vancomycin) and Group B without the use of topical antibiotic. The primary outcome measure was to assess sternal wound infection prior to discharge till 30th postoperative day. Results: Sternal wound infection was found to be more common in Group B than Group A (17.91% vs 5.97%) and was statistically significant (p 0.005). Deep sternal wound infection(DSWI) did not develop in patients of Group A as compared to 4.47% of patients of Group B. Deep Sternal wound infection was more common in females than males (p 0.001). DSWI related mortality was none in Group A verses 1.49% in Group B (0.006). Conclusion: Topical Cefoperazone-sulbactam plus Vancomycin plays important role in the prevention of sternal wound infection especially deep sternal wound infection after coronary artery bypass grafting surgery.

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