Khawaja Tahir Maqbool, Sehrish Rashid, Arslan Shehzad, Sidra Rafique.
Frequency of side effects of sofosbuvir and daclatsavir in patients of chronic Hepatitis C.
J Rawal Med Uni Jan ;23(3):138-42.

Background:Hepatitis is a common problem in Pakistan. Pakistan is the second most prevalent country regarding hepatitis C with a prevalence rate of 6.7%. Genotype 3 is the most commonly detected genotype in Pakistan. This study was conducting in Hepatitis Clinic, Medical Unit II, Jinnah Hospital Lahore and study duration was three months starting from 1stDec 2018 to 28thFeb 2019.In our study we evaluate side effects of direct acting antivirals forhepatitis C patients by using descriptive case series.Methods: Forty patientsmeeting the inclusion criteria were included in the study. All patients were then given direct anti-virals for a period of three months. Patients were called after every four weeks and observed for the presence of side effects like fever, fatigue, malaise, generalized weakness, myalgia, nausea and vomiting. Data was entered and analyzed in SPSS version ver.21.0. Frequency and percentages were calculated for demographic and clinical profile and side effects. Mean and Standard deviation was calculated for biochemical values at base line and end of therapy. Chi-square test was used to assess side effects among age, gender and duration of disease and paired t test for biochemical parameters with p < .05 as statistical significance.Results: Mean age of the patients was 39 years + 11.6. Fever was recorded in 72.5% fatigue was seen in 52.5%, malaise was recorded in 37.5% and generalized weakness was noticed in 37.5. Myalgia was recorded in 12.5% and nausea and vomiting were reported in 2.5% of patients. . (p> .05). There was a statistically significant difference between mean baseline and at end treatment values for AST, ALT, AP and TLC. ( P< .05). Conclusion: Our study concluded that along with efficacy advantage of DAA therapy, their safety profile is acceptable in terms of adverse drug reaction of immediate or during treatment however long term follow up is needed to ascertain and apprehend the safety matters linkedwith the utilization of DAAs.

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