Saima Naureen, Javaria Fatima, Bushra Shaheen, Rizwan Waseem, Tooba Malik, Sheikh Maria Qammar.
Drug Induced Liver Injury with Diclofenac and Febuxostat Combination in Mice at Histopathology.
Pak J Med Health Sci Jan ;13(4):722-4.

Febuxostat is a novel drug administered for the treatment of hyperurecemic state; usually it leads to gout flare during first few days of treatment and joint pain aggravates. In such situations patients are advised to take Diclofenac to alleviate pain. A study was planned to explore the hepatotoxic effects of this combination. Six groups were arranged having 10 mice in each. Group I was given normal saline which served as control. Group II administered Diclofenac (100 mg/kg) . Group III treated with Febuxostat (50 mg/kg). Group IV, Group V and Group VI were treated with drug combinations. In these three groups dose of Diclofenac was same (100 mg/kg) and dose of febuxostat gradually increased as for Group IV 5 mg/kg, Group V 10 mg/kg and Group VI 50 mg/kg. After 7 days of treatment, liver tissue preserved for histopathological assessment from each animal. Liver injury was evaluated by examining liver macroscopically as well as histologically.

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