Wardah Siddique, Nazia Rashid, Neelofar Yousaf Warraich, Amina Asghar, Haseeba Talat, Ayela Eman Zia, Ajaz Fatima.
Evaluation of histopathological changes in isoniazid and rifampicin induced liver injury and protective role of zinc sulfate in albino rats.
Pak J Med Health Sci Jan ;13(4):809-16.

Background: Hepatic disorders are becoming major health issue. Presently available treatment options in hepatic failure cases are not 100% curative except organ transplantation which is not cost effective . Development of inexpensive treatment option is needed so regenerative supplements offer good approach for prevention of hepatic dysfunction. Zinc sulfate supplementation can prevent liver damage by antioxidant effects . Aim: To find out histoprotective effect of Zinc Sulfate 7mg /kg/day against Isoniazid 50mg/kg/day and Rifampicin 100 mg/kg/day induced histopathological changes. Methods/ results : Twenty one albino male rats were included in study . All are divided in GX, GY and GZ (Seven rats in each group). Histopathological changes were induced by Isoniazid and Rifampicin in GY, Z. Histoprotection of Zinc sulfate supplementation was evaluated in GZ by microscopy of following features eosinophilic infiltrate, lobular lymphocytic infiltrate, portal lymphocytic infiltrate, portal and lobular plasma cellular infiltrate, perivenular necrosis, bridging/ confluent necrosis, steatosis, fibrosis, neutrophils, sinusoidal distension, hepatocytes enlargement, inflammed portal area, congestion, prominent kuppfer cells and mast cells . Significant changes in parameters like lobular lymphocytic infiltrate, portal lymphocytic infiltrate, portal and lobular plasma cellular infiltrate, steatosis , neutrophils, sinusoidal distension, hepatocytes enlargement, inflammed portal area, congestion, prominent kuppfer cells and mast cells (p-value 0.05) were observed among various groups. Conclusion: This study provided histopathological evidence of hepatoprotective effect of Zinc sulfate supplementation.

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