Masood Ahmed, Humayun Riaz-ud Din Haider, Shehzad Bashir, Zumra Mahmood, Mahnoor, Mujahid Hussain.
Perioperative antibiotic use for surgical site infection in penetrating hollow viscus injury – a placebo -controlled study.
Pak J Med Health Sci Jan ;13(4):851-4.

Background: Blunt penetrating hollow viscus injuries (HVIs) deserve empiric perioperative antibiotic use to stay away bacterial infection particularly surgical site infection (SSI) . Aim: To compare the efficacy of 5 days with 24 hours perioperative antibiotic use for SSIs in the HVIs. Place and duration: Govt Allama Iqbal and Sardar Begam Teaching hospitals; January 2018 - June 2019. Methodology: A combination of 1g sulbactam + cefoperazone and 500mg metronidazole was administered intravenously to each of the male adult (aged: 18 to 65 years) patients of penetrating HVI before (x1) and after (x3 at the interval of 8 h) of surgery. For Group A (N = 80) , the same dosing regimen was continued for next four days i.e. total 5 days while Group B (N = 79) received normal saline placebo , parallelly. Subjects were examined for any SSIs in follow up session. Results: A patient with transfusion of Packed RBCs had approximately 10 -fold (95%CI:1.663 –69.847, p =.0001) more chance of the SSI than patients without transfusion. The SSI appeared in 13 (8.2%) patients of group A and B ( 3 vs. 10 , respectively). Antibiotic susceptible S. aureus was identified in the surgical wounds of 2 (66.6%) patients of Group A while antibiotic resistant E. coli was predominant in Group B 8(80%). Conclusion: Perioperative antibiotic use for 5 days is better than 24 hours on HVI regarding incidence of SSI and bacterial isolates.

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