Ali Abbas, Kumayl Abbas Meghji, Shazia Parveen Channar, Muhammad Saqib Baloch, Muhammad Shahab Hanif, Ahsan Aslam.
Effects of escitalopram and citalopram on histology of testicular tissue in Wistar albino rats.
Pak J Med Health Sci Jan ;13(4):936-8.

Aim: To determine the comparative effects of Escitalopram and citalopram on and testicular histology. Methods : This quasi experimental study was conducted during 10 weeks in the Department of Pharmacology Isra University Hyderabad with the cooperation of Animal House, Sindh Agricultural University Tando Jam. Normal and healthy rats with weight of 200-300 g rams were studied. Total 50 albino rats were divided into the 5 groups. Group A animals were given normal chow diet ad libitum. Groups B and E animals underwent Escitalopram 0.4mg/kg orally for 6 weeks. Groups C and D were given citalopram 0.8mg/kg for 6 weeks. The drugs were administered orally. After 6 weeks, testes of groups A, B and C animals were removed and in Groups D and E drugs were stopped for 4 weeks and then testes were removed by same procedures in order to see either the effects of drugs are reversible or not. Results : In this study mean weight of tastes in group B and Group C were decreased as compared to control group and reversal group D and group E, while findings were statistically insignificant, p -value 0.092. Decreased spermatogenesis and sertoli cell hyperplasia was found in 5 and 4 rates of experimental group B and group C respectively , which were improved in 3 albino rates of D and 3 albino rates of group E. Conclusion: Escitalopram and Citalopram both have harmful effects on testicular weight and histology, while after withdrawal of these drugs these harmful effects may be cured .

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