Faheem Mahmood, Muhammad Fahimul Haq, Maira Mahmood, Sana Sarmad, Amna Noor, Qasim Saeed, Mudassar Ali, Umber Nisar, Shama Akram, Samiah Shahid, Arslan Saleem, Abdul Majeed Cheema.
The hormonal levels of progesterone in second and third trimesters of gestational diabetes mellitus patients with or without family history.
Pak J Med Health Sci Jan ;13(4):957-61.

Background: Gestational diabetes mellitus (GDM) is intolerance of glucose with varying degrees of severity which is initially recognized during pregnancy. GDM generally has few symptoms and it is commonly diagnosed during pregnancy by screening . Aim: In the present study the responses of the pertinent hormone of the pregnancy progesterone have been investigated in gestational diabetes and non-GDM subjects especially in context of positive and negative family history in second and third trimester. Methods: The present cross sectional 2 stage study with non -probability convenient sampling was done in Arif Memorial Teaching Hospital and Hameed Latif Hospital Lahore. 110 pregnant females from rural and urban areas of Lahore were the study population, out of which 55 had GDM and 55 were controls/non-GDM. After taking their consent on consent Performa general data of the pregnancy and blood samples were taken . Results: Serum progesterone was estimated by ELISA with specific monoclonal antibodies. The results were analyzed in relation to GDM, non -GDM, positive and negative family history in second and third trimesters. In second trimester Progesterone exhibited 4 times and 3 times increases in positive and negative family history subjects respectively compared to respective non -GDM groups In third trimester also the responses of these hormones were numerous times increases in GDM than non -GDM. Conclusion: The analysis of results of the hormones within GDM and non -GDM category and between the trimesters has shown some statistically noticeable results. The excessive increase of progesterone do support that it may be one of the cause of insulin resistance in GDM.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com