Abdul Sattar, Lubaba Mukhtar, Muhammad Naeem Afzal.
Antibiotic susceptibility pattern of uropathogens in a tertiary care hospital.
Pak J Med Health Sci Jan ;13(4):992-4.

Aim : To investigate the frequency of bacterial isolates in patients with UTI and their sensitivity to commonly used antibiotics in Sialkot, Pakistan. Methods: A total of 695 samples were collected from suspected patients of UTI, referred to Khawaja M Safdar Medical College, and Abdul Sattar Lab, Sialkot during a period of 1 year from July 2017 to June 2018. The antimicrobial sensitivity was checked via Kirby-Bauer disc diffusion method for the cultured isolates. Results : Out of 695 patients (232 males, 463 females), 321 (46.2%) yielded bacterial growth, while 15 (2.1%) had candida in urine. E. coli was most frequent isolate (79.1%), followed by Enterococcus (12.7%), and Enterobacter (3.1%). Most useful antibiotics were meropenem (96.6%), imipenem (96.2%), fosfomycin (93.8%), Piperacillin / Tazobactam (88.8%), and nitrofurantoin (87.8%). The most effective drugs against E. coli were Carbapenems (97.2%), fosfomycin (93.7%), Amikacin (92.9%), Piperacillin / Tazobactam (88.6%) and Nitrofurantoin (88.2%). E. coli had very high resistance against Quinolones (almost 70%) and Cephalosporin (almost 80%). Co-amoxiclauv was effective in 48% of bacteria. Fosfomycin and nitrofurantoin were the only oral options among most effective antibiotics. 3.4% (11/321) bacteria were resistant to Carbapenem. Conclusion: Our results highlight alarming resistance to commonly used antibiotics, and highlight the sensitivity of broad spectrum drugs, like carbapenems, piperacillin / tazobactam, fosfomycin, and nitrofurantoin. Our results call for revision of current practices of treatment of urinary tract infection.

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