Baseera Imran, Sana Rasheed Chaudhry-ameeryddin Medical College Lahore, Komal Iqbal, Samita Yasmin, Isma Meer, Muniza Saeed.
Reduced heart rate variability in frequency domain in patients of chronic obstructive pulmonary disease.
Pak J Med Health Sci Jan ;13(4):1335-8.

Chronic Obstructive Pulmonary Disease is characterized by a progressive partially reversible, airflow obstruction. As the disease advances, COPD is linked with cardiac comorbidities due to disrupted functioning of autonomic nervous system. A vagally stimulated pattern of oscillations is generated between adjacent R -R intervals in electrocardiographic recording, which is known as Heart Rate Variability (HRV). In diseases influencing sympathovagal balance such as COPD, variability between R -R intervals is reduced. This produces a constant pattern of ECG, known as reduced HRV. The purpose of study was to assess and compare parameters of HRV in frequency domain in patients of COPD with healthy subjects .I n this study, 69 non obese male subjects in the age range of 50 -70 years were included. HRV was assessed using Holter Monitor. It was analyzed in frequency domain using KUBIOS HRV 3.3 .0 STANDARD software. Spirolab III was used for Pulmonary Function Tests (PFTs).Data was analyzed by SPSS version 23. Results indicated that Median IQR for HF, comparing diseased groups was enhanced with disease severity (p value ˂ 0.05). It was concluded that HRV reduced in COPD patients as compared to healthy in fre quency domain . However with disease advancement HF which reflects vagal modulation was increased.

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