Humera Nazir, Aijaz Zeeshan Khan Chachar, Muhammad Jamshed Khan, Sajid Abaidullah.
Frequency of Osteoporosis in patients of Chronic Liver Disease.
Pak J Med Health Sci Jan ;13(4):717-9.

Aim : To determine the frequency of osteoporosis in patients of chronic liver disease. Settings: South Medical ward , Mayo Hospital, King Edward Medical University Lahore. Study Design: Cross sectional survey. Duration of Study : This study was conducted from 1 st January to 30th June, 2014. Methods : Total 100 patients having chronic liver disease falling in the inclusion criteria were selected using 5% level of significance, 6.5% error margin and 11.5% of expected percentage for osteoporosis. Bone mineral density (BMD) (g/cm 2) of the lumbar spine and the left proximal femur (if not involved by disease, in other case the right proximal femur) was measured by dual energy x -ray absorptiometry (DEXA) with the use of a discovery W model by single technician. Tscore at these areas were also noted and interpreted for presence or absence of osteoporosis. The data was entered and analyzed into SPSS version 23.0. Results: Age range of the patients was 30-75 years with the mean age of 53.9 ±10.6 years. There were 42 (42%) male patients and 58(58%) female patients. Out of total 100 patients only 12(12%) patients were found to have osteoporosis and 88(88%) patients had no evidence of osteoporosis. There were 29 (29%) patients who were diagnosed to have osteopenia and 59(59%) patients had normal bone density (BMD). Conclusion: We have concluded that Osteoporosis is common in patients having chronic liver disease. Osteoporosis becomes more evident and it has been frequently seen in patients with prolonged duration of liver disease.

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