Ahmad Hasan, Shahzad Tawab, Muhammad Arif, Muhammad Muzamil, Aqib Javed, Muhammad Aslam.
Effect of gender on efficacy of streptokinase in acute ST segment elevation myocardial infarction.
Pak Heart J Jan ;52(3):254-7.

Objective: To study the relation of gender with the efficacy of thrombolytic therapy. Methodology: It is a cross sectional study conducted from December 2017 to July 2018 at Jinnah Hospital Lahore. Patients from single center fulfilling the eligibility criteria for thrombolytic therapy and receiving the therapy were included and were followed during their hospital stay and their hospital outcome was recorded SPSS version 22 was used for analysis. Results: Among 780 patients 52.6% (n = 410) were males. The resolution of chest pain within 90 mins occurred more in males (69.5%) as compared to females (49.7%)(p =.000), wash-out phenomenon was more in males (72.9%)as compared to females (51.6%) (p = .000), ST resolution (22.4% in males 21.6% in females) (p=.783) and reperfusion arrhythmias (18.3% in males vs 16.2% in females) (p 0.444). Cardiac failure [15.9% in females vs 9.3% males (p=0.005)], reduction in LV ejection fraction (LVEF) [(10.8% in females vs 5.6% in males (p = 0.008)], sudden cardiac death during hospital stay [females (8.6%)vs males (4.4%) (p=0.015)], immediate hypotension [females 27.3% vs 24.9%(p=0.442)], malignant arrhythmias requiring intervention [females (10%) thanin males (6.6%) (p=0.83)] were more in females as compared to males. Conclusion: Female gender is more prone to complications with less beneficial clinical response to thrombolytic therapy as compared to their counter part gender.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com