Mohammed Aqil, Uzma Azmatullah, Shua Nasir, Ateeque Ahmed Khan, Lal Shehbaz.
Diagnostic accuracy of Sonomamography in carcinoma breast using biopsy as the gold standard in pre-operative cases.
Pak J Surg Jan ;36(1):8-12.

Objective: To determine the diagnostic accuracy of sonomammography in carcinoma breast using biopsy as the gold standard in pre-operative cases. Material and Methods: A cross sectional study involving 114 participants took place in a tertiary care government hospital in Karachi, Pakistan. The selected patients were those referred for mammography who were reported as Breast Imaging-Reporting and Data System (BIRA DS) Category IV and V (suspected case of breast carcinoma and biopsy advised for confirmation). Ultrasound examinations were then correlated and final result obtained after biopsy. Results: Ultrasound detected carcinoma in 38 (33.3%) cases true positive cases was 32 and true negative cases were 68. Sensitivity, specificity, PPV, NPV were 80%, 91.9%, 84.2%, 89.5% and 93% respectively. Mammography detected carcinoma in 38 (33.3%). True positive cases were 33 and true negative were 60. Sensitivity, specificity, PPV, NPV and accuracy were 82.5%, 81.1%, 70.2%, 89.6% and 93.9% respectively. The diagnostic accuracy of combination of US and mammography was 99.1%. Sensitivity, specificity, PPV, NPV was 97.5%, 91.9%, 86.7% and 98.6% respectively. Conclusion: Whole breast ultrasound or mammography does not possess enough diagnostic value when evaluating breast carcinoma. However, if used in adjunct, they complement each other to improve diagnoses significantly

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