Javeria Iftikhar, Rabbia Zubair, Lubna Habib, Mir Arsalan Ali, Arfeen Azam Khan, Nida Saeed.
In search of an alleviating drug in the management of mastalgia, danazol or evening primerose oil: our recent experience.
Pak J Surg Jan ;35(3):205-8.

Objective: To study the recent outcomes of management of mastalgia treated by Danazol and Evening Primerose oil. Study design: Descriptive observational study Study setting: Department of Surgery, Hamdard University Hospital Duration: For a period of 12 months: from December 2016 to December 2017 Material and Methods: The candidates were selected on basis of double blinded, consecutive sampling. Females with complains of Mastalgia, coinciding with our inclusion criteria were administered danazol, evening primerose oil in divided doses for a period of 6 weeks and they were assessed for pain alleviation by the Cardiff Breast Pain score. Results: In our study the results showed Danazol to be significantly effective in the management of Mastalgia as compared to the efficacy of evening primrose oil. In Group-A, the average Cardiff breast pain score of those candidates receiving Danazol at 4 weeks was 2.19 and at 12 weeks was 1.23, which signifies the efficacy of the drug in relieving pain. The Mean Cardiff breast pain score of group-B at 4 weeks was 2.77 and at 12 weeks was 2.03 reinforcing its use not strongly beneficial for patients in mastalgia. Conclusion: We concluded that although with mild, tolerable and reversible adverse effects Danazol has a promising role in management of cyclical in women.

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