Ubaidullah Khan, Muhammad Azeem Subhani, Mimpal Singh.
Comparison of Nebulized Versus Systemic Corticosteroid for Management of Children Presenting with Acute Exacerbation of Asthma.
Pak Paed J Jan ;44(3):236-9.

Objective: To compare the mean forced expiratory volume in 1 second with nebulized versus systemic corticosteroid therapy for management of children presenting with acute exacerbation of asthma. Study Design: Randomised controlled trial. Place and Duration of study: Pediatric Medicine Unit II, Mayo Hospital, Lahore from July to December 2017 Material and Methods: Total of 100 cases (50 cases in each group), age 5-12 years of either gender presenting with acute exacerbation of asthma were included. FEV1 was noted at baseline. In group A, children were given nebulized salbutamol (100+-g every four hours for 48 hours) plus beclomethasone (40ug/kg every 12 hours, for one week, each dose contained 250+-g). In group B, children were given nebulized salbutamol (100+-g every four hours for 48 hours) plus injectable dexamethasone (0.6mg/Kg every 12 hours for one week). All patients were followed-up in OPD for 7 days. Both groups were compared for mean FEV1 by using independent sample t-test. P-value<=0.05 was considered as significant. Results: Children in group A had mean FEV1 significantly higher as compared to group B i.e. 119.54 vs. 104.94, p-value=0.000. and the same effect was seen in all age groups of patients, gender as well as for weight of children respectively. Conclusion: Nebulized corticosteroid is more effective in terms of better respiratory function than systemic corticosteroid for treating children with acute exacerbation of asthma.

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