Neelofar Ghaffar, Maira Riaz, Shahzia Soomro, Bilquis, Misbah Iqbal Hanif, Khemchand Moorani.
Diagnostic Accuracy of Spot Urine Protein-Creatinine Ratio in Children with Nephrotic Syndrome.
Pak Paed J Jan ;44(3):219-23.

Objective: To determine the accuracy of urine protein creatinine ratio with 24-hour urinary protein excretion in the diagnosis of childhood nephrotic syndrome. Study design: Cross-sectional study Place and duration of study: This study was conducted in Pediatric Nephrology ward and OPD, National Institute of Child Health, Karachi from 15th March 2011 to 14th September 2011. Material and Methods: Total 130 children aged 1 to 12 yrs who fulfilled the inclusion criteria were studied after taking the informed consent. The SPSS version 15 was applied to analyze the data. Results: Mean spot urine protein creatinine ratio was 14.3 +- 10 and 24 hours urine protein were 102.7 +- 54.6 mg/m2/hr. Accuracy of spot urine protein creatinine ratio with 24 hour urinary UP in children with nephrotic syndrome was 118 (90.8%). Conclusion: Spot urine protein creatinine ratio is as accurate as 24 hour UP with the diagnostic accuracy of 90.8%.

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