Muhammad Aamir, Barka Urooj, Safia Fatima, Asif Ali Memon, Sobia Irum Kirmani, Muhammad Tahir Khadim.
Pattern of arterial blood gases disorders in ICU setting.
Pak J Pathol Jan ;31(1):7-10.

Objective: To determine the frequency and percentage of metabolic and respiratory acid base disorders in neonatal and adult intensive care units. Material and Methods: This cross-sectional study was conducted in department of chemical pathology & endocrinology, Armed Forces Institute of Pathology, Rawalpindi from Jan 2018 to December 2018.A total of 261 blood samples were collected in neonatal and adult Intensive Care Setting (ICU) from patients indwelling arterial catheters, sealed anaerobically, chilled, heparinized and sent for immediate analysis of Arterial Blood Gases (ABGs) on COBAS b 221 by potentiometric and voltammetry principles. Statistical analysis was done on SPSS 21.Result: Among 261 patients, 163 (62.5%) were male and 98(37.5%) were females. Test of normality (Shapiro-Wilk) was significant (p-value <0.001) showing non-parametric nature of data. The median age was 49 years with interquartile range (IQR) 33years. When age was divided into different groups; <18 years was 24 (9.2%), 18-25years was 21 (8.0%), 26-35 years 46 (17.6%), 36 -45 years was 35 (13.4%) and >45 years was 135 (51.7%).Outcome analysis of arterial blood gases (ABGs) showed; Only two (0.8%) patients had evidence of normal results, 49(18.8%) had partially compensated metabolic acidosis, 13(5.0%) were suffering from partially compensated metabolic alkalosis,14(5.4%) with partially compensated respiratory alkalosis, 49(18.8%) had partially compensated respiratory acidosis, 98(37.5%) with double disorder metabolic acidosis and respiratory alkalosis, 9(3.4%) with double disorder metabolic acidosis and respiratory acidosis, 14(5.4%) with double disorder metabolic alkalosis and respiratory alkalosis, 9(3.4%) double disorder metabolic alkalosis and respiratory acidosis, 2(0.8%) with uncompensated respiratory acidosis and 2(0.8%) with uncompensated respiratory alkalosis. Conclusion: Metabolic acidosis with respiratory alkalosis i.e. double acid base disorder was the commonest acid base disorders in critically ill patients(both neonate and adult) because of multi-organs disease and without any significant difference among male and female patients.

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