Sadia Shaukat, Shabnam Hamid, Aiza Saadia.
Protective effect of soyabean oil on alveolar septal thickness induced by bisphenol A.
Pak J Pathol Jan ;27(3):119-23.

Objective: To assess the protective effect of soyabean oil on alveolar septal thickness induced by Bisphenol A in alveoli of adult mice. Study design: Laboratory based randomized control trial. Place & duration of study: This study was conducted at Department of Anatomy, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad from November 2015 to June 2016.Materials and Methods: Forty male and female BALB/c mice were chosen and divided into four groups, each with 10 animals. Group A served as control. Group B was given BPA at a dose of 50milligram/kilogram body weight/day. Group C was treated with soyabean oil at a dose of 500 milligram/day. Group D received BPA at a dose of 50milligram/kilogram body weight/day and soyabean oil at a dose of 500milligram/day. All treatments were given once daily for a period of 8 weeks. Animals were dissected 24hrs after the last dose. Lung tissue processing and H&E staining was done for routine histological study. Alveolar septal thickness was morphometrically and statistically analysed. Results: Alveolar septal thickness was significantly increased (>3 times normal) in group B in comparison to groups A, C and D and slightly increased in group D in comparison to groups A, B and C. Conclusion: BPA increases the alveolar septal wall thickness in lungs of adult mice but subsequent administration of soyabean oil protects against thickening of septa.

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