Hassan Tariq, Muhammad Zubair, Shoaib Naiyar Hashmi, Saeed Afzal, Syed Naeem Raza Hamdani, Saad Tariq, Waqas Ranjha, Arooj Shahid.
Clnico-pathological spectrum of breast carcinoma - study of 1764 cases.
Pak J Pathol Jan ;27(3):110-8.

Background: Breast cancer is the second most common malignancy among women, next to Cervical cancer. Understanding the pathogenesis, morphological features and its risk-factors, including family history can help in the treatment, early detection and prevention of the disease. Data on the epidemiological profile of breast cancer patients from Pakistan is scarce due to the lack of systemic data collection systems and resources. Our Institute caters to patients from population of all strata and is a representation of cases at all hospitals in Armed Forces. Study design: Descriptive cross sectional. Place & duration of study: A retrospective audit of breast cancer patients presenting at a tertiary referral center (AFIP) from 2010 to 2015.Materials and Methods: In an attempt to evaluate the clinico-morphological patterns of breast cancer patients, including their family history a detailed analysis of 1764 breast cancer cases diagnosed during the years 2010-2015 was carried out. Frequency, Mean and standard deviation were performed. Results: Mean age of the patient at presentation was 47.4 years, ranging from 4-90 years. Among the various histo-morphological types, infiltrating duct carcinoma (IDC) was found to be commonest type i.e. in 1574 cases (89.2%), followed by infiltrating lobular carcinoma (ILC) in 47 cases (2.7%), Mucinous carcinoma 26(1.5%), Invasive papillary carcinoma 17(1%) and other types forming (0.9%). Recurrent carcinoma made up 35 (2%) of the cases. Lymph node positivity was observed in 540 cases (30.64%). Out of 1764 cases evaluated for presence of family history, 1163cases (65.9%) revealed positive family history of cancer. 64 cases (3.4%) were males while 1704 case (96.6%) were females. Conclusion: Family history of breast cancer forms one of the major risk factor among the various determining factors for the development of breast cancer and for its early detection. It is important to take an appropriate history of cancers from the patients' relatives to identifying the high risk group. Mean age of initial presentation of carcinoma is also shifting to younger age groups due to better screening methods and awareness. Various morpholological subtypes of breast cancer have different prognostic and predictive implications. Educating the population about the risk factors would be helpful in early detection of breast cancer.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com