Muhammad Irfan Karamat, Asad Aslam Khan, Tahseen Maju.
Prophylactic role of Intra-Vitreal Bevacizumab(Avastin) in Diabetic patients under Going Phacoemulcification.
Ann King Edward Med Uni Jan ;25(1):17-21.

Abstract Objectives: To study the effect of pre-operative intra-vitreal Avastin (bevacizumab) in diabetic patients undergoing phacoemulcification on central macular thickness and best corrected visual acuity. Methods: A randomized controlled trial was conducted which included 42 patients (N=42). Group A and B had 21 patients each. Group A patients received injection Avastin (Bevacizumab) one week before phacoemulcification and Group B patient underwent phacoemulcification alone. Pre-operative best corrected visual acuity (BCVA) and central macular thickness (CMT) was recorded before giving intravitreal bevacizumab. Post-operative BCVA and CMT was noted 4 weeks after the surgery. Results: The difference in final visual acuity between Group A and B was not statistically significant. Change in CMT from pre-operative value was not significant in study population (p=0.364), but was statistically significant in both groups individually (p=0.029, 0.001 respectively). Conclusion: Our study concludes that cataract surgery along with prophylacticintra-vitreal Avastin (bevacizumab) may contribute in short term improvement of macular thickness, but does not have any statistical significant effect on final BCVA.

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