Muhammad Athar Sadiq, Marwa Salim Al Habsi, Sunil Kumar Nadar, Muhammad Mujtaba Shaikh, Hafidh Aqeel Baomar.
Transient contrast induced neurotoxicity after coronary angiography: a contrast re-challenge case..
Pak J Med Sci Jan ;36(5):1140-2.

Contrast induced neurotoxicity (CIN) is a rare complication of cardiac catheterization and re-exposure to contrast medium carries the risk of recurrent CIN. We report a case of successful contrast re-challenge in a 60-year-old female patient who developed CIN after her first procedure of coronary angiography (CAG) which resulted in symptoms of disorientation, amnesia and cortical blindness. A non-contrast enhanced CT performed four hours after the CAG was normal, however, her MRI brain scan showed scattered tiny hyper intensities in posterior occipito-temporal and parietal regions suggesting CIN. Patient's symptoms resolved completely after 72 hours. Two months later, because of persistent exertional angina, patient was successfully re-challenged with lesser amount of contrast medium with administration of hydrocortisone prior to procedure, and PCI to LAD was completed without recurrence of CIN.

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