Hanif Memon, Shahina Hanif, Farhan Saeed, Muhammad Iqbal, Muhammad Athar Khan, Fatima Siraj, Aisha.
Effect of Maternal Colonization with History of Prolonged Rupture of Membrane on Neonatal Colonization and Early Onset Sepsis.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;24(4):195-9.

Objective: To determine the effect of maternal colonization with history of PROM on neonatal colonization and early onset sepsis. Methods: A descriptive cross-sectional study was carried out at a single tertiary care hospital of Kara-chi from June 1st 2018 to May 31st 2019. A total of 155 patients' full-term newborns between 37 to 41weeks of gestation with history of rupture of membranes more than 18 hours duration was selected by convenience sampling method. High vaginal swab was collected of all full-term pregnant women with history of PROM. After delivery of their new-borns, all babies were kept in nursery under closed observation for 72 hours duration and their blood cultures, CRP (C- Reactive Protein) and CBC (complete blood count) was sent within 24 hours of delivery. Results: In our study, out of 155 PROM cases 58 (37.4) were growth positive and 50 (32.3) neonates had positive blood C/S at delivery. Out of 58 cases with suspected growth positive PROM mothers 51had gram negative organisms in HVS while only 7 mothers were gram positive in HVS. Of all neo-nates with positive blood C/S at delivery 44 cases were gram negative organisms in their blood. Conclusion: In our study organisms found in high vaginal swab of mother are similar to the organ-isms found in the blood culture of their new-born with early onset sepsis.

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