Shazia Nazar, Afshan Mehboob, Sara Rafique.
Association of Serum Vitamin-D and Omentin-1 Levels in Post-Menopausal Female with Coronary Artery Disease.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;25(2):76-81.

Objective: The objective of the present study was to investigate the association between serum vita-min-D (calcidiol, D2) and omentin-1 levels in pre- and post-menopausal female patients with coronary artery disease (CAD).Methods: This cross-sectional, case-based study was conducted in cardiac ward of Civil Hospital Karachi during July 2016 to June 2017. Total 110 diagnosed female patients of coronary artery dis-ease were included randomly in the study, out of which, 42 women were pre-menopausal, whereas,68 post-menopausal. Diagnosis was based upon coronary angiography. Serum Vitamin-D andomentin-1 levels were determined by using enzyme linked immunosorbent essay (ELISA) in Dr. Abdul Qadeer Khan Institute of Biotechnology and Genetic Engineering (KIBGE). Serum vitamin-D concentrations were classed as sufficient ( 30 ng/mL); deficient (10 to< 29 ng/mL); and insufficient ( <10 ng/mL). Data was analyzed by SSPS version 16.Results: From our study we observed significant low levels of serum vitamin-D and omentin-1 in pre-and post-menopausal females of coronary artery disease, however, severe deficiency of Vitamin-D(<10 ng/L) was more associated with post-menopausal females. Vitamin-D deficiency (<30ng/L) was found in 82.72% (n=96) of CAD females, moreover; 46.36% (n=51) patients were found with severe vitamin-D deficiency placed in group I, 40.90% (n=45) patients were found with moderate deficiency(17.09 +- 4 ng/mL) in group II, whereas only 12.72% (n=14) had optimal serum vitamin-D levels placed in group III. Serum vitamin-D (calcidiol, D2) level was associated positively with omentin-1 in CAD patients after adjustment for potential confounding variables; basal metabolic rate, waist circumference, blood pressure and lipid profile in multivariable linear regression analysis. Conclusion: within the limits of the study, we concluded that low levels of vitamin-D and omentin-1 are associated with both pre and post-menopausal females with prevalent coronary artery disease (CAD). Further investigations are required in different ethnic groups and populations to confirm the findings.

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