Fatima Muslim, Noorul Amina, Nabila Khan, Hemasa Gul, Shah Muhammad Jadoon, Anila Hayat.
Efficacy of clomiphene citrate & metformin versus clomiphene alone in the treatment of primary infertility in obese women with polycystic ovarian syndrome.
Pak J Surg Jan ;36(2):185-9.

Objective: To compare the efficacy of clomiphene citrate & metformin versus clomiphene alone in the treatment of primary infertility in obese women with polycystic ovarian syndrome. Study design: Randomized controlled trial Settings: Th is study was performed at department of Obstetrics and Gynaecology, Mardan Medical Complex and Teaching Hospital, Mardan from 9th September, 2018 to 9th March, 2019. Material and Methods: After approval from the ethical committee, a total of 760-females, suffering from PCOS with infertility, were included in the study. All the included women were randomly allocated in two groups by lottery method. Women in group-A were subjected to metformin plus clomiphene citrate. Women in the group-B were only subjected to clomiphene citrate. All the women in both groups were followed up regularly till next 3-months and unprotected intercourse two to three times per week was advised to all women in either groups. Women in both the groups were screened by urinary pregnancy test until 3-months from start of therapy if a woman presents with clinical suspicion of pregnancy. Results: Average age of the patients was 24.77 +- 8.12 years. Fertility was achieved in 98 (25.8%) cases in group-A while in 68 (17.9%) cases in group-B, which was significantly high in group-A with p-value=0.008. Conclusion: Metformin plus clomiphene is more effective than clomiphene alone in the treatment of primary infertility due to polycystic ovarian syndrome in obese women.

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