Hizbullah Jan, Misbah Riaz, Attaullah Khan, Tufail Ahmad, Mah Muneer Khan, Erum Khalid.
Susceptibility patterns of common uropathogens to oral antibiotics in adults and their role in empiric treatment of urinary tract infection.
Pak J Surg Jan ;36(2):146-51.

Objective: To determine the frequencies of ESBL and Carbapenemase producing uropathogens and their susceptibilities to oral antibiotics in adults in a tertiary care hospital in Peshawar. Material and Methods: Th is retrospective study was conducted at Surgical-B Unit of KTH, Peshawar from January 2016 to December 2017. Adult patients whose urinalysis showed numerous pus cells on microscopy were included. Antimicrobial profiling was done by Kirby Bauer Disc Diff usion method. ESBL detection and screening for Carbapenem resistant strains was done by routine phenotypic methods. Frequencies and percentages of common uropathogens in the adult age group were calculated and their susceptibility patterns to different oral antibiotics was determined. SPSS 23 was used for data analysis. Results: Of the 2,100 urine samples processed, 762 (36.3%) showed significant growth, of which 407 (53.4%) were multidrug resistant. E.coli was isolated in76.9% cases. ESBL producers comprised 49.3% and carbapenemase producers 4.2% of the total growths. Uropathogens showed high sensitivity to Fosfomycin (91.3%) and increased resistance towards Fluoroquinolones (77-80%), Cefixime (89.2%), Trimethoprim-Sulphamethoxazole (89.5%) and Ampicillin (94.4%). Conclusion: Fosfomycin has increased sensitivity for ESBL and carbapenem resistant strains of E.coli. Therefore, the rising antimicrobial resistance against Fosfomycin mandates it`s cautious use in empirical treatment of UTI.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com