Rabbia Zubair, Masoom Raza Mirza, Lubna Habib, Javeria Ift Ikhar, Batool Zehra.
Role of tranexamic acid in prevention of seroma formation after ventral hernioplasty.
Pak J Surg Jan ;36(2):126-9.

Objective: To see the role of tranexamic acid in seroma formation after ventral hernioplasty. Study design: Cross sectional study. Place and duration of study: General surgery department of Hamdard University hospital (HUH), from April 1st 2016 to March 30th 2017. Material and Methods: Patients were selected by non-purposive convenience sampling. 70-patients undergoing Mesh Hernioplasty for ventral hernias under general anesthesia are included and divided into two equal groups. Patients with BMI of 18-24.99 were selected. Hernias that require mesh of 15x15 cm and patient with ASA 1 and 2 are included. Age range is 18-60 years. Recurrent and incisional hernias are excluded. Injection Tranexamic acid 1G TDS for 48 hours. Drains were kept till the output is less than 30ml/day. Total output was measured and compared in two groups. Results: In Group 1 (patients who received tranexamic acid post-operatively), out of 35 patients only 11-patients had total drain output of <150ml, 19-patients had total drain output between 150-300 ml and 5-patients had drain output of >300 ml. Total drain output of all patients was 7,000 ml with an average of 200ml/patient. In Group 2 (patients who didn`t receive tranexamic acid), out of 35-patients none had drain output <150ml, 12 patients had drain output between 150-300ml and 23 had drain output >300ml. Total drain output of all patients was 11,200 ml with an average of 320ml/patient. Conclusion: Our study showed decrease in post-operative seroma formation after intravenous administration of Tranexamic acid for 48-hours. It also reduces the total time of drain removal.

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