Saeeduddin, Khanzada AWK.
Thermodynamic dissociation constant studies of Caffeine at different temperatures and in organic water solvent mixture.
Pak J Pharm Sci Jan ;17(1):83-7.

Thermodynamic dissociation studies have been carried out potentiometrically at various temperatures from 25 to 50oC and in 10, 20, 30 and 40% v/v dioxane-water solvent mixture at 25oC. The influence of temperature and nature of solvent on dissociation equilibria of caffeine is being investigated A computer program in GW-BASIC has been used to calculate the pK values.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com