Aunaza Maqbool, Rabia Sharif Bhatti, Muhammad Usman Arshad, Zamir Iqbal, Sohail Zia, Masud-ul Hasan.
Comparison of Effects of Topical Loteprednol Etabonate and Topical Dexamethasone on Intraocular Pressure after Cataract Surgery.
Al-Shifa J Ophthalmol Jan ;15(3):9-15.

Objective: To determine the efficacy of loteprednol etabonate in terms of maintaining intraocular pressure between 12-21mm of Hg after cataract surgery, compared to dexamethasone. Study Design: Randomized control trial. Study Duration and Setting: The study was conducted at the Department of Ophthalmology, Benazir Bhutto Hospital, Rawalpindi between December 2015 to June 2016. Materials and Methods: A total of 362 patients undergoing cataract extraction were included in the study. Any activity in terms of cells and flare was checked in the anterior chamber of the eye pre and postoperatively. Patients of group one were given loteprednol etabonate and patients of group two were given Dexamethasone. Later their intraocular pressure was checked with Goldman applanation tonometer one day before and 28 days after cataract extraction. Results: The mean+ SD age of the study patients in group one was 54.5+ 3.56 years ranging from 18 to 60 years while of study patients in group two was 53.87+4.49 years ranging from 18 to 60. Out of 181 patients in group one 51.9% were males while in group two 50.8% were males. Mean IOP on day 01in study patients of group one was 18.17+2.11 and mean IOP on day 01 in study group two was 18.18+ 2.17. mean IOP on day 28 in study group one was 19.04+ 1.86 and of group two was 19.27+2.07.Conclusion: Dexamethasone and Loteprednol have almost an overlapping spectrum in terms of controlling postoperative intraocular inflammation however Loteprednol Etabonate is better at maintaining the intraocular pressure after cataract surgery.

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