Ghazal Mansoor, Rabia Sattar, Sana Qanber, Ejaz Ahmed, Hassan Shafique, Ayesha Zahid.
Study of Lipid peroxidation Marker (MDA) and Vitamin C in Pregnancy-Induced Hypertension.
J Sharif Med Dent Coll Jan ;4(1):21-5.

Objective: To determine the levels of malondialdehyde (MDA) and vitamin C in hypertensive pregnant women as compared to normotensive pregnant women and non-pregnant control subjects. Methodology: It was a cross-sectional descriptive study conducted at Sharif Medical City Hospital (SMCH). The study was approved by the ethical committee of the hospital. Eighty subjects (including 35 hypertensive pregnant women, 35 normotensive pregnant women and 10 non pregnant control subjects) attending the Gynaecology OPD of SMCH were enrolled in the study. Consecutive sampling technique was used. Venous blood was collected, centrifuged and obtained serum was used for the estimation of malondialdehyde (MDA) and vitamin C. Results: Malondialdehyde was significantly increased in pregnancy-induced hypertensive women when compared with the normotensive pregnant women and non-pregnant control subjects. On the other hand, the level of vitamin C was significantly reduced in pregnancy-induced hypertensive women as compared to other study subjects. Conclusion: The levels of vitamin C are decreased in pregnancy-induced hypertension. So, vitamin C supplementation in the early weeks of gestation might decrease the oxidative damage and improve maternal and perinatal outcome. Keywords: Pregnancy-induced hypertension (PIH). Lipid peroxidation. Malondialdehyde. Vitamin C.

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