Areeja Fatima, Asad Zain, Muhammad Tauseef Javed, Muhammad Shahid Iqbal.
Factors Predisposing To Cleft Lip and Palate in Children Presenting in a Tertiary Care Hospital.
J Sharif Med Dent Coll Jan ;4(1):12-6.

Objective: To determine the predisposing risk factors of cleft lip and palate among children presenting in a tertiary care hospital. Methodology: It was a case-control study conducted at the Children Hospital & Institute of Child Health, Lahore for a period of 3 months. The study was approved by the ethical committee of the hospital. Purposive sampling was done to obtain 55 cases and 55 controls. Data collection tool employed a questionnaire which was then analyzed by SPSS 22. Frequencies, odds ratios and data were presented in tables. Results: The mean age of children was found to be 8.25 months. Among the cases, 10(18.2%) cases suffered from cleft lip alone, 23(41.8%) suffered from the cleft palate and 22(40%) suffered from both cleft lip and palate. Two(3.6%) cases also had congenital heart disease. Bivariate analysis of the variables in the study showed that only female gender with a p-value of 0.01, cousin marriage with a p-value of 0.004 and lack of multivitamins/folic acid supplementation during pregnancy with a p-value of 0.034 were significant while differences observed in cases and controls in all other variables were not significant. Conclusion: Female gender of the child, cousin marriage and lack of multivitamin/folic acid supplementation during pregnancy were found to have a significant association with the development of cleft lip and palate. Keywords: Congenital abnormalities. Cleft lip. Cleft palate.

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