Hassan Jamil, Hina Bashir, Saba Iqbal, Samina Kausar, Maham Younis, Qurat-ul Ain.
Assessment of Oxidative Stress in Diabetic and Nondiabetic patients of Acute Myocardial Infarction.
J Sharif Med Dent Coll Jan ;5(1):28-31.

Objective: To assess the level of oxidative stress with malondialdehyde (MDA), catalase (CAT), glutathione (GSH) and superoxide dismutase (SOD) in diabetic and nondiabetic patients of acute myocardial infarction (AMI). Methodology: It was a cross-sectional comparative study done at the Institute of Molecular Biology and Biotechnology, The University of Lahore. The study was conducted from June to September 2017. The research protocol was approved by the ethical committee before the conduction of study. Informed written consent was taken from all the patients. A total of 300 subjects attending the Punjab Institute of Cardiology and Services Hospital, Lahore including 138 diagnosed cases of AMI, 132 diagnosed cases of diabetes with AMI and 30 healthy subjects as a control group were enrolled in this study. Blood samples were collected, centrifuged and processed to estimate MDA, SOD, CAT and GSH. Data was statistically analyzed and presented by using the Graph Pad Prism 5 software. Results: The results of our study indicate that SOD, CAT and GSH levels were significantly decreased in diabetic AMI patients as compared to AMI patients and control subjects. On the other hand, the MDA level was found increased in diabetic AMI patients when compared with AMI patients and normal control subjects. Conclusion: Diabetic patients who also suffer from AMI are more prone towards the risk of oxidative damage as compared to patients who just have AMI because the oxidative stress markers damage cardiac cells and the prognosis in diabetic AMI patients is also poor. Diabetic patients must be careful towards their health and should make a check on their diet to avoid AMI. Keywords: Oxidative stress. Malondialdehyde. Catalase. Glutathione. Superoxide dismutase.

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