Maimona Tabbsum, Sana Akram, Hamid Javaid Qureshi, Chaman Nasrullah, Muhammad Jabran Javaid Sindhu, Jahanzaib Salim.
Effect of Vitamin D on Testosterone Levels in Male Albino Rats under Atorvastatin Administration.
J Sharif Med Dent Coll Jan ;6(1):42-6.

Objective: To determine the effect of atorvastatin on serum testosterone levels and the effect of vitamin D on testosterone levels in atorvastatin taking male rats. Methodology: It was a randomized control trial conducted in the animal house of Akhtar Saeed Medical & Dental College (AMDC), Lahore. A total of 90 male albino rats were taken and divided into three equal groups by random sampling technique. Group Awas a control group, group B was given atorvastatin 10 mg/kg body weight per oral for 6 weeks and group C was given atorvastatin in the same dose plus vitamin D 100 ng/kg/day for 6 weeks. At the end of the 6 week, blood samples were taken through the cardiac puncture for serum testosterone levels. The significance of difference was calculated by one way ANOVA. Results: Levels of testosterone were 3.90+0.192 ng/ml in group A, 3.10+0.343 ng/ml in group B and 3.47+0.748 ng/ml in group C. Testosterone levels were significantly decreased (p-value=0.000) in rats under atorvastatin administration (3.10+0.343 ng/ml) as compared to control rats (3.90+0.192 ng/ml). Testosterone levels were significantly raised (p-value=0.000) in rats treated with atorvastatin along with vitamin D supplementation (3.47+0.748 ng/ml) in comparison to those rats treated with atorvastatin alone(3.10+0.343 ng/ml). Conclusion: Atorvastatin decreases serum testosterone levels and vitamin D ameliorates atorvastatin induced decline in serum testosterone levels. Keywords: Vitamin D. Testosterone. Atorvastatin

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