Uzma Jabbar, Rukhshan Khurshid, Mazhar Mushtaq, Hafiza Hina Pasha, Hasan Akbar Khan, Samra Hafeez.
Effect of Plasma Chromium on Oxidative Stress Biomarkers in Pharmaceutical Workers.
J Sharif Med Dent Coll Jan ;6(1):37-41.

Objective: To estimate the levels of chromium in workers of the pharmaceutical industry and its effects on the level of oxidative biomarkers. Methodology: A cross-sectional comparative study was carried out on workers of two pharmaceutical industries named group 1 and group 2.A total of 48 workers working in two pharmaceutical industries that use chromium as an ingredient in drugs were included in the study. Twenty five healthy age-matched males were included in group 3 as controls. Estimation of serum chromium was carried out by Atomic absorption spectrophotometer. Levels of antioxidant enzymes were estimated by different standard chemical methods. Results: Mean age of the study participants was 25.6+5.6 years in group 1, 32.5+2.4 years in group 2 & 30.146.3 years in group 3. Serum chromium level was 3.62EUR1.9 ug/L, 3.99+1.79 ug/L & 0.15+0.01 ug/L in group 1, 2 and 3, respectively. Serum chromium was significantly raised (p-value <0.0001) in group 1 & 2 as compared to controls (Group 3). No significant difference was found between group 1 and 2 (p value=0.491). Levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) were significantly increased in both group 1 & 2 as compared to controls (Group 3). Conclusion: The significant effect of chromium level was observed on the oxidative stress biomarkers in workers working in all sections of the pharmaceutical industries. Keywords: Chromium. Pharmaceutical workers. Anti-oxidant enzymes. Malondialdehyde

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