Mudasar Zia, Uzma Jabbar, Rukhshan Khurshid, Samra Hafeez, Humna Ashraf, Maira Mahmood.
Serum Uric Acid and Homocysteine Levels as Predictors of Preeclampsia in Young Pregnant Women.
J Sharif Med Dent Coll Jan ;6(2):72-6.

Objective: To find out the role of serum uric acid and homocysteine levels as predictors of preeclampsia in young pregnant women. Methodology: A cross-sectional study was carried out at Lahore General Hospital from a period of May 2017 to February 2018. A total of 35 consented preeclamptic women in the 24 and 35 trimester of pregnancy (preeclamptic pregnant group) with an age range of 21-28 years were included in the study. Thirty consented age-matched pregnant women with no history of any disease were taken as normotensive pregnant controls. Women with a blood pressure of 140/90 mmHg and proteinuria were considered as preeclamptic pregnant females. Questionnaires based on age, gestational period, parity, etc. were filled by both groups. Blood samples of both patients and controls were collected and analyzed for the serum levels of uric acid and homocysteine. Collected data was analyzed by Statistical Package for the Social Sciences (SPSS) version 20. Results: Mean age of preeclamptic pregnant females was 35+6 years with a mean BMI of 30 kg/m". Their mean blood pressure was 143.55/93.87 mmHg. The majority of the pregnant women included in the study belonged to a poor socioeconomic class with a history of obstetrical complications like abortions in previous pregnancies. Significantly increased levels of serum uric acid and serum homocysteine were observed in the preeclamptic pregnant group as compared to the normotensive pregnant control group. Conclusion: Levels of serum uric acid and homocysteine are raised in preeclamptic pregnant females. Estimation of maternal hyperuricemia and hyperhomocysteinemia can be a good parameter for assessing the prognosis and management of patients with pregnancy induced hypertensive disorders including preeclampsia. Furthermore, these serum markers may play an important role in understanding the etiology and pathogenesis of preeclampsia. Keywords: Hyperuricemia. Hyperhomocysteinemia. Preeclampsia.

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