Sadiqa Bano Haider, Junaid Khan M Taha Ha , Sikandar Ali Mahesar, Rooque Umar M Farooque, Syed Hussain Mehdi, Abdullah Muttaqi.
Comparison of lateral anal spincterotomy and 0.2% Glyceryl trinitrate (GTN) in the treatment of chronic anal fissure.
Pak J Surg Jan ;36(4):292-8.

Background and objective of the study: Anal fissure is a very painful condition. The trauma occurs through defecating hard stool or liquid stool with the hyper-tonicity causing anal pain with or without bleeding is the primary feature of anal fissure. In this study, we compare the success rate of the two different treatment modalities by dividing the patients into 2 groups, group I: 0.2% GTN (Glyceryl trinitrate) (GTN), group II: lateral spincterotomy. Material and Methods: A comparative retrospective study was conducted at surgical department of Jinnah Medical College Hospital between March-2019 to February-2020. Eighty (80) patients were included in this study which were divided into two groups. 1st group receive 0.2% GTN and second group underwent lateral sphincterotomy for chronic and fissure. 40-patients were included in each group. Assessment was done on the basis of cessation of disease features after twelve weeks of treatment: bleeding per rectum, perianal pain and constipation. Results: In group I (0.2% GTN CREAM): 73 % patients were completely healed and another 18% healed with mild perianal pain and pruritus. In group II (lateral sphincterotomy): 73% patients were healed without any symptom, while 0.2% healed with mild perianal pain and pruritus.

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