Aysha Mansoor Lodhi, Asma Mushtaq, Muhammad Nasir Rana, Wajiha Rizwan, Muhammad Sahir Saud.
Clinical and Laboratory Profile and Response to Antibiotics in Typhoid Fever.
Pak Paed J Jan ;45(2):169-74.

Objective: To study the clinical and laboratory profile and response to antibiotic therapy in typhoid fever. Study Design: Quasi experimental study Place and Duration of Study: The Children`s Hospital, Lahore from December 2019 to May 2020. Material and Methods: Total of 200 patients between 01 to 15 years of age who fulfilled the criteria of confirmed and clinically suspected cases. Data was analyzed by SPSS 20. Results: There were 120 males and 80 females. 52% of patients were under 5 years of age. Only 6% were using boiled water. Mean duration of fever was 14 +- 6 days. The most common symptom was anorexia (57%) and clinical sign was coated tongue (52%). Blood cultures were positive in 21%. All isolates were 100% sensitive to azithromycin and meropenem. None were sensitive to ciprofloxacin, ampicillin and chloramphenicol. 28% were sensitive to co-amoxiclav, 14% to Co-trimoxazole, 9.5% to ceftriaxone and cefixime each, 85% to amikacin and 81% to piperacillin-tazobactam. 37% patients responded to ceftriaxone, 35% to azithromycin and 25% to meropenem. Conclusion: Sensitivity pattern has revealed a significant proportion of multidrug and extensively drug resistant strains. Continued surveillance of resistance patterns and formulation of antibiotic therapy for a step wise approach accordingly as in our study for their judicious use is the need of hour.

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