Zoya Shaikh, Ghulam Haider, Khalil, Bhunisha.
Frequency of different histopathological types of esophageal cancer patients at oncology department of a tertiary care hospital in Karachi.
J Fatima Jinnah Med Uni Jan ;14(4):161-5.

Background: Around the globe, the carcinoma of the esophagus is the eight most prevalent cancer with an incidence of 456,000 cases per year and is the sixth cause of cancer mortality. There are two major histological subtypes of carcinoma of the esophagus, esophageal squamous cell carcinoma and adenocarcinoma. The aim of current study is to evaluate the frequency of different histopathological types of esophageal cancer in patients presenting at tertiary care hospital of Karachi. Patients and methods: It was a cross-sectional study conducted at the Department of Clinical Oncology, Jinnah Postgraduate Medical Center, Karachi from March 2017 till March 2019. Two hundred and one histologically proven cases of esophageal cancer of in patients of either gender and between 15-80 years of age were included. Patients were interviewed and data regarding age, gender, education, marital status, employment status, addictions like cigarette or huqqa smoking, consumption of pan, betel nut, naswar, or gutka were recorded. Endoscopy and histology and computed tomographys can were performed. Stage, site, grade and type of tumor were noted. SPSS version 23 was used to analyze data. Mean and SD were calculated for quantitative variables. Frequency and percentage were calculated for qualitative variables. Chi-square test was used to assess the significance between age and gender with type of EC. Results: Mean age of the patients was 47.84. Majority of the patients had stage 2 of cancer (42.8%) and lower tumor site (62.2%)Squamous cell carcinoma was the most common histopathological type in 137 patients out 201(68%). The age, gender, smoking, consumption of pan, grade, site and stage of tumor showed statistical significant difference when compared with esophageal squamous cell carcinoma and esophageal adenocarcinoma. Conclusion: The burden of esophageal squamous cell carcinoma is dramatically increasing in Pakistani population and squamous cell carcinoma was the most common histopathological types.

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