Muhammad Zahid Ali, Irfan Younus Bhatti Rajput, Sohail Yousaf, Muhammad Javed, Khalil Iqbal, Faiza Altaf.
Frequency of myocarditis in patients with COVID-19 and in-hospital mortality.
J Cardiovascular Dis Jan ;17(2):103-6.

BACKGROUND: Corona virus infection has become a recognized infectious disease spreading in several countries of the world. Number of cases of COVID-19 are increasing day by day in whole world. Previous studies showed that COVID-19 is rapidly deteriorating disease in patients suffering from chronic illness. This study is conducted to determine the Incidence of myocarditis in patients with COVID19 and in-hospital mortality AIMS & OBJECTIVE: To see the frequency of myocarditis in patients with COVID-19 and in-hospital mortality. MATERIAL & METHODS: This observational cohort study was carried out at corona ward of Aziz Bhatti Shaheed Teaching Hospital, Nawaz Sharif Medical College, Gujrat from 15 to 30th March 2020. Fifty five patients between 15-70 years of age, admitted with positive PCR results for covid-19 were included in this study after informed consent; patients with prior history of any cardiovascular, pulmonary or other co-morbidity were excluded while patients having history of hypertension, diabetes or smoking were included in the study. All the patients remained admitted for 14 days. Patients were evaluated clinically, by ECG, troponins and Echocardiography for diagnosis of myocarditis. Global hypokinesia and ejection fraction less than or equal to 40% were used to diagnose myocarditis with no other cause. Patients were managed conservatively. Frequency of myocarditis and in-hospital mortality was noted. Successful treatment towards hospital discharge was relief of clinical symptoms, a-febrile, clear chest X-Ray and at least two consecutive negative PCR for covid-19. p value RESULTS: Out of fifty five, 5(9%) patients were diabetics and 4 were hypertensive. Five (9%) developed mild pneumonia which recovered conservatively and three (5.4%) patients developed myocarditis. There were 7% patients hypertensive and 9% were diabetic. One (1.8%) patient expired having myocarditis. Duration of follow up was only during hospital stay. So our in-hospital mortality was 1.8%, p value was calculated as significant < 0.05. CONCLUSION: Myocarditis is a known but less common complication of COVID-19. Cardiac injury is more in those with previously having cardiovascular or other comorbidities. In healthy and immunocompetent population its incidence is quite low. KEYWORDS: COVID-19, Myocarditis, in-hospital mortality

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