Zaidi SBH, Khan M A, Hodges N G, Sial A Y.
Efficacy of Nebulised Colomycin in Bronchiectasis.
Pak Armed Forces Med J Jan ;53(2):208-11.

Bronchiectasis is a chronic debilitating disorder due to the destruction of the bronchial walls and their supporting tissues. It is often complicated by acute-on-chronic bacterial infections. The purpose of this study was to assess the efficacy of nebulised colomycin in reducing the need for hospitalisation and intravenous antibiotic treatment in patients with bronchiectasis. This was a retrospective case control study. It was carried out at the Department of Chest Medicine, Gwynedd Hospital, Bangor, NW Wales, UK, and covered a period of sixty two months from Sept 1996 to Nov 2001. Records of all patients with established bronchiectasis receiving nebulised colomycin during Aug & Nov 2001 were retrieved and analysed for the number of admissions before and after commencing treatment with colomycin. Data was also collected, regarding sputum culture reports at the time of admission. There was an apparent reduction in the number of admissions after starting nebulised colomycin in patients with bronchiectasis. However, the response was not uniform among all patients and there were several other factors contributing to this. The study suggests that use of nebulised colomycin may be helpful in maintaing patients with bronchiectasis in stable state and reduce their need for hospitalisation. However a more elaborate, multi-centre prospective study is needed to confirm this impression/finding.

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