Usman Mehmood, Sohail Mahmood Ch.
Testosterone Undecanoate as an Effective Treatment in Men with Idiopathic Oligoasthenozoospermia.
J Surg Pak Jan ;24(1):23-7.

Objective: To assess the effect of treatment with the androgen testosterone undecanoate on seminal variables and frequency of pregnancy in subfertile men with idiopathic oligoasthenozoospermia. Study design: Descriptive Case Series. Place & Duration of study: Department of Obstetrics & Gynaecology, Bahawal Victoria Hospital & Civil Hospital Bahawalpur, from December 2015 to December 2018. Methodology: Men, aged 18-50 years, who visited the outpatient department with the complaint of infertility were enrolled in this study. They were given testosterone undecanoate 40mg t.i.d for 3 months and followed up for another 3 months without treatment. Seminal analysis was done after 3 days of abstinence, before and after treatment as well as at the end of a 3-month treatment-free follow up period. Results: A total of 1800 patients were included. Asthenozoospermia was the most common abnormality, found in 76.1% (n=1370) of the sample. The baseline mean sperm concentration was 16.65 +-7.14x106/ml and the mean percentage of progressively motile sperm was 17.21+- 13.52%. These parameters increased to 54.28 +- 20.11x106/ml and 35.07+- 16.39% at the end of 3-month follow up period, respectively. Pregnancies were achieved in 469 (26.05%) female partners of male patients during the study period. Conclusion: Testosterone undecanoate has tangible positive effects on seminal parameters leading to conceptions among subfertile couples.

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