Bushra Gohar Shah, Saira Mushtaq, Asma Saeed, Mohammad Faisal Khan, Asad Javed.
Comparison of disease activity in anti-mutated citrullinated vimentin positive and anti-mutated citrullinated vimentin negative subjects with rheumatoid arthritis.
Ann Allied Health Sci Jan ;7(1):17-20.

Objective: To compare disease activity in anti-mutated citrullinated vimentin (MCV) positive and anti-MCV negative subjects with rheumatoid arthritis. Material & Methods: A cross-sectional study was carried out at University of Health Sciences Lahore. Fifty eight diagnosed rheumatoid arthritis subjects who fulfill the American College of Rheumatology criteria were recruited from Fatima Memorial Hospital. For laboratory investigation, venous blood sample was obtained from the participants. Serum extraction was performed through centrifugation and placed at -20C for further investigation. Anti-MCV antibodies was evaluated using ELISA. Disease Activity Scores (DAS-28) scoring was done in both groups (aMCV +ive and aMCV -ive Rheumatoid arthritis patients) and comparison was done. Results: Considerable difference was noted in the DAS-28, tender joint count, swollen joint count and erythrocyte sedimentation rate of Anti-MCV +ive and Anti-MCV-ive patients. Conclusion: Anti-MCV +ive subjects disease activity scores were higher as compared to Anti-MCV-ive patients.

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