Sadaf Munir, Nighat Bhatty, Kausar Almas, Muhammad Nawaz, Farida Manzoor, Syed Jawwad Husain.
Estimation of protein metabolites endogenous creatinine and urea in the blood of male volunteers.
Pak J Med Res Jan ;42(4):157-9.

Endogenous creatinine and urea are waste products of protein metabolism. Their levels in the blood reflect status of the kidney function. Objectives: The study was aimed to determine levels of these protein metabolites in teenaged male individuals under normal kidney function. The data collected would part with existing baseline data of plasma creatinine and urea levels under normal conditions. Study Design: This was an unpaired observational study. Setting: Faculty of Veterinary Sciences, University of Agriculture, Faisalabad. Subjects and Methods: The study included 30 male individuals (students) believed to be in their normal kidney function assessed from relevant information collected individually on a questionnaire. Plasma creatinine and urea concentrations in the subjects were determined spectrophotometrically following Jaff and Endpoint-Berthelot procedures. Results: Mean ± SD values of plasma creatinine and urea in the individuals were found to be 1.49 ± 0.10 mg/dl and 19.4 ± 3.63 mg/dl, respectively. Conclusion: The results concluded that the mean levels of both these protein metabolites were within the ranges of their values for normal kidney function in teenaged males.


USER COMMENTS

I have reviewed the full-text of this professionally low-standard article with no finding. In this study serum creatinine and urea levels were determined in male volunteers to assess the renal function. What did the authors conclude from the findindgs of this study. Creatinine and urea levels rise only in the subjects with renal dysfuntion, while in apparently normal subjects what is the objective to determine the levels of these two biochemical parameters in the serum while there were no study groups to compare the reslults. The main flaw of the study is that various varibles like age, weight, body surface area, etc were also measured but no correlation of these variables was determined (by regression analysis) with either serum creatinine or urea, reflecting the illiteracy of the authors with the basic statisiticaly analyses. What are being published in our journals? HONESTY GROUP ....
Posted by: honesty on Jul 2004

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