Khalil Ullah, Iftikhar R, Moin S, Badsha S.
Post transplant complications.
Pak J Med Res Jan ;42(4):174-8.

Objective: To review complications, mode of mortality in our patients population and describe autopsy findings. Design: A retrospective data based study of renal transplant complications and autopsy findings in two cases. Place and duration of study: The study was conducted at Military Hospital, Combined Military Hospital and pathology Dept, Army Medical College, Rawalpindi over a period of 23 months. Subjects and methods: Post-transplant complications in 41 patients were studied alongwith autopsy findings of two cases related to some of these complications. Results: Renal disease requiring transplantation were glomerulonephritis (61%), hypertension (24.4%), diabetic nephropathy (4.9%), hypertension with diabetic nephropathy (4.9%), nephrotoxicity (2.4%) and renal calculi (2.4%). Thirty eight of the donors were live related. Complications after transplantation included rejection, jaundice, acute tubular necrosis, diabetes mellitus, renal stones, acute myocardial infarction, hydronephrosis, accidental damage, septicaemia, cardiac failure and urinary fistula. Deaths in 13 cases were due to hyperacute rejection, acute rejection, hepatic failure, cardiac failure, septicaemia, diabetes mellitus and generalized fungal infection. Autopsy findings in one case showed generalized fungal infection and in other renal vessel thrombosis with infarction of allograft kidney. Conclusion: Transplantation is a procedure that needs state of the art approach thoughout this modality of therapy to avoid myriads of complications. Autopsy is educating and helps in understanding its pathophysiology and complications.

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