Aisha Bano, Faheem Tahir, Fazli Subhan, Sikandar Sultan, Fariyal Deepa, Syed Shakeel Raza Rizvi, Mazhar Qayyum, Ali Abbas Qazilbash, Azra Khanum, Birjees Mazhar Kazi, Athar Saeed Dil.
A preliminary study of gonadotropin ratios among infertile Pakistani men.
Pak J Med Res Jan ;42(4):185-7.

Objective: The present study is a preliminary attempt to determine the gonodotropin ratios in different combinations of these hormones among the Pakistani men representing infertile couples. Method: Serum concentration of FSH and LH were determined in all the subjects (n=42), which were then divided into six groups, on the basis of normal, hypo and hyper secretions of these gonadotropins. Levels of LH and FSH were evaluated at the Reproductive Physiology/Health laboratories, using EIA technique. Statistical Analysis: Data representing age as well as the hormonal levels, were statistically analyzed by application of the students `t` test. Results: In the first group, the LH and FSH levels were within the normal range, and the LH/FSH and FSH/LH ratios being 1.55 ±0 06, 0.85 ±0 0.1 respectively. In group 2 with normal LH and high FSH, these ratios were 0.51±0.67 and 2.0 ±0.26 respectively and in group 3 with low LH and high FSH, they were 0.11±0.00 and 8.8 ±0.00. In group 4 with hyper LH and normal FSH the LH/FSH ratio was 2.34±0.63 and FSH/LH ratio was 0.25±0.1, while in group 5 with low LH and low FSH these were 1.4±0.00 and 0.71±0.00 respectively. In the last group, which comprised of subjects with elevated levels of both these gonadotropins, LH/FSH ratio was 1.03±0.19 and FSH/LH ratio was 1.60±0.50. Conclusion: The present data indicate that disturbance in gonadotropin ratios also causes infertility, since these hormones act synergistically.

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